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B12 or supplements, as vitamin B12 is only found naturally in foods of animal origin

References ACS Chemical Biology (2023) Synthetic ERR// Agonist Induces an ERR-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity Journal of Pharmacology and Experimental Therapeutics (2024) A Synthetic ERR Agonist Alleviates Metabolic Syndrome Circulation (2024) Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function American Journal of Pathology (2023) Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

Its ability to restore NAD+ flux links it directly to the growing field of mitochondrial medicine