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(2022) have explored that the -elemene integrated with erlotinib enhanced the cytotoxicity of erlotinib against EGFR mutated primary EGFR-TKI resistant NSCLC cells, and diminished the content of ferroptosis negative regulatory proteins (glutaminase, FTH1, Nrf2, Slc7a11 and GPX4), added ROS and lipid peroxidation levels, and accomplished anti-tumor effects through ferroptosis

Can J Anaesth 2024

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This is largely because retatrutide has not yet completed the full regulatory approval process, and comprehensive drug interaction studies particularly those involving commonly used supplements have not been publicly reported