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Keywords: acetaminophen, N-acetyl- p -benzoquinonimine, NAPQI, cytotoxicity, single nucleotide polymorphisms, SNPs, expression array, mRNA, Human Variation Panel, GWAS Acetaminophen is widely used as an over-the-counter analgesic and antipyretic agent

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The overexpression of LCN 2 leads to resistance to 5-FU in CRC cell lines in vitro and in vivo by decreasing intracellular iron levels and stimulating the expression of GPX4 and SLC7A11 ( Lymphoid-specific helicase (LSH) is involved in ferroptosis and is a potential therapeutic target in cancer because of its crucial role in ferroptosis