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KCs are identified primarily as CD45 + F4/80 high CD11b int CLEC4F + Timd4 + cells, and MoMFs are characterized by the CD45 + F4/80 int CD11b high expression

Deficiencies in complex I proteins are the most common causes of mitochondrial diseases in humans and these disorders encompass a wide degree of heterogeneity in pathological presentation

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2.3.1 Background ALS is a serious and progressive disease that damages both the upper and lower motor neurons, which are the nerve cells that control voluntary muscle movement