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In the last decades, it has been shown that aminochrome, the product of dopamine autoxidation, can induce most of these changes and that the rate of some of them is pH dependent (Garca-Moreno et al., substantia nigra are especially susceptible to dopamine neurotoxicity compared to the more resistant dopaminergic neurons in the ventral tegmental area

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Therefore, the outcome in our study has High reliability

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