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While the American Academy of Pediatrics Clinical Practice Guideline recommends initiating obesity medications for adolescents 12 years old with obesity, as adjuncts to lifestyle interventions8, this trial, along with future data evaluating liraglutides long-term effectiveness and its potential impact on weight regain upon discontinuation, may change the current standard of care for pediatrics with obesity

An improved understanding of the mechanisms underlying glucose-lowering by metformin would provide the potential to refine its clinical application in the management of type 2 diabetes

Eli Lilly funded

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