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TABLE 1 Key cardiovascular outcomes results for selected GLP-1 receptor agonists

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Furthermore, when the obesogenic status was reduced, the expression of amylin and GLP-1 receptors in the DVC remained stable, suggesting that even in a weight-reduced state form obesity, the DVC GLP-1R and amylin receptors theoretically remain as viable drug targets for sustaining weight loss with continued pharmacotherapy

For 503B facilities, beyond-use dating should be supported by product-specific stability studies - actual testing of the specific formulation under specified storage conditions over time, measuring potency, pH, sterility, appearance, and other parameters at defined intervals