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doi: 10.1016/j.maturitas.2017.06.025 257 Escorcia MoraPValbuenaDDiez-JuanA

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The body's adaptation to significant caloric restriction and metabolic changes during weight loss can also contribute to feelings of tiredness

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Placebo groups lost only 23%

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Phase 2 results have been published in The New England Journal of Medicine

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