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Since immune cell trafficking into the CNS is tightly regulated by the blood brain barrier which selectively only allows entry of immune cell subsets required for immune surveillance (80), it remains unknown if CAR-T would efficiently reach senescent cells in the brain parenchyma

While the observed weight loss in the Look Action for Health in Diabetes study improved cardiovascular parameters, it did not reduce the morbidity and mortality associated with CVD, measured as cardiovascular events

The SELECT cardiovascular outcomes trial demonstrated a 20 percent reduction in major cardiovascular events, suggesting benefits beyond weight loss that may justify long-term use even after weight goals are achieved

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