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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Duarte M.E., Kim S.W

Impaired Adult Neurogenesis Recent studies suggest that impaired adult hippocampal neurogenesis may be an early etiological factor in Alzheimers, affecting neuronal migration and network formation prior to the appearance of amyloid or tau pathology

CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle

If youre comparing access paths for oral GLP-1 care, TrimRxs article on how oral GLP-1s work offers a useful overview