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Microglia are under circadian clock control, with robust hippocampal TNF, IL1, and IL6 expression, peaking during the light or inactive phase in male Sprague-Dawley rats, with increased cytokine expression in response to an immune stimulation with lipopolysaccharide (LPS) during the light/inactive phase ( Bmal1 expression (Takano et al., 2009), along with a circadian variation in markers involved in oxidation, NADPH oxidase 2 (Nox2), and inflammatory TNF, IL1 and IL-6 in microglia increased during the light or inactive phase in nocturnal mice

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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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