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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

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Potential Research Applications: Metabolic regulation and energy balance studies Appetite suppression and satiety signaling research Glucose metabolism and insulin response models Exploration of novel GLP receptor analog activity For laboratory research only

(5) Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ