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There is no established safety data for the combination in any population, so the honest position is that contraindication data does not exist at the combination level

In published radioligand competition assays, tirzepatide binds the human GIP receptor with an affinity comparable to native GIP itself (Ki in the low picomolar range), while its affinity for the human GLP-1 receptor is approximately five-fold lower than that of native GLP-1

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Clinical studies document specific benefits including retinal neuroprotection through neurotrophic factors, improved ocular blood flow enhancing nutrient delivery to photoreceptors, reduced inflammation in age-related macular degeneration, cellular repair accelerating recovery from retinal injury, and potential prevention of progressive vision loss in diabetic retinopathy