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c , Representative images of intestine stained with MitoSOX Red dye in N2, isp-1(qm150) or nuo-6(qm200) animals grown on OP50 at early or late L4 stage

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In activated macrophage cultures, GHK-Cu administration reduces the production of pro-inflammatory cytokines including interleukin-1, tumor necrosis factor-, and interleukin-6 by 40-65% while simultaneously increasing the production of anti-inflammatory mediators such as interleukin-10 and transforming growth factor-

However, the timing can vary depending on the severity of the deficiency and individual metabolic response