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One reason for this is that the weights are much heavier, and the final repetition is to fatigue. To clarify, you cannot budge the weight for the last rep you do, and you feel the burn. There is good, quality research on the efficacy of the super slow protocol

Endothelium xanthine dehydrogenase interacts with xanthine oxidase (XO) producing O and H 2 O 2 , and thus, generating another source of free radicals (Turrens, 2003) (Figure 1)

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Notably, the emission intensity of all compounds was much stronger in water than in methanol, suggesting their potential AIE activity (Supplementary Fig