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If no refrigerator is available, keep the insulated bag closed as much as possible and replace gel packs with fresh ice wrapped in a barrier (like a Ziploc bag inside a towel) if the original packs warm up

In that case, stop using the product right away (if its a topical, gently wash it off with cool water) and seek prompt medical attention

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Unknown Long-Term Effects : Long-term risks remain unclear because controlled human studies have not established durable safety outcomes, organ effects, cancer-related concerns, or interaction risks