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In analyses of GLP1RA CVOTs in which MACE in subjects with and without prior HF were assessed (LEADER, EXSCEL and HARMONY), the HRs were always 0.05), suggesting consistent effects irrespective of subjects CV risk at baseline.2, 3, 4, 35 Post hoc analyses of CVOTs also support the CV effects of GLP1RAs in subjects with T2D across the spectrum of CV risk

The trial was designed to exclude a pre-specified risk margin of 1.3 for the hazard ratio of MACE comparing TRESIBA to insulin glargine U-100

1 Long MD, B, et al

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