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Murine models of blood storage have identified genetic factors that contribute to the altered capacity of stored RBCs ( e.g., the ferrireductase STEAP3) 11,12 and mitigate oxidative damage ( e.g., activation of the pentose phosphate pathway by G6PD to generate reducing equivalents) 1315

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Remember that thioredoxin reductase can regenerate ascorbate from dehydroascorbate in the theorized antioxidant network (shown below)