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Amino acid derivatives, Furthermore, aspartyl phenylalanine (Asp-Phe) could stabilize HIF-1 by competitively inhibiting prolyl hydroxylase (PHD), forming a metabolic-hypoxic positive feedback loop, while a small-molecule inhibitor targeting its synthetase, Phgdh, could reduce synovial thickness by 42% in a collagen-induced arthritis (CIA) animal model (81, 82)

Gut-derived Tregs help maintain immune tolerance

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