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However, the evidence for superiority over subcutaneous administration remains unclear, and the increased complexity and discomfort of IM injection discourages its use for most individuals

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The advantage of our measurement of the Glutathione Index (GSH/GSSG) is therefore, that it shows changes in GR activity, not only due to higher/lower GR gene activity but also due to the absence of the reaction cofactor NADP. As a result, dementia patients have a lower potential to dynamically fight free radicals and will have a worse GSH/GSSG, which we call the Glutathione Index (7)

They found that after seven days, there was about a 30% increase in average glutathione levels in the subjects' brains