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a patients were taught to self inject b we could buy injectable B12 OTC This paper from 1983 focuses on pernicious anaemia rather than the many other causes of B12 deficiency, much like today, patients who do not have a definitive diagnosis of PA are considered to be in need of less treatment (or none at all) despite the severity of symptoms being exactly the same

Compared to subcutaneous injections, nasal sprays are non-invasive, painless, and easy to use, which supports frequent dosing

Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

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