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Of note, the effects of chronic activation or inhibition of POMC neurons differ between sexes, since female mice show resilience to chemogenetic manipulations of ARC POMC neurons despite similar electrophysiological changes under stress [151]

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Eli Lilly pleaded guilty to a US federal criminal misdemeanor charge of illegally marketing Zyprexa, actively promoting the drug for off-label uses, particularly for the treatment of dementia in the elderly