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Phase 2 data (published 2023) Phase 2 results published in the New England Journal of Medicine in 2023 provided the first substantial evidence for the mechanism, reporting dose-dependent body-weight reductions reaching approximately 24% at the highest doses, HbA1c improvements comparable to or exceeding tirzepatide, a safety profile dominated by gastrointestinal tolerability effects, and energy-expenditure increases documented by indirect calorimetry

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By targeting norepinephrine, dopamine, and serotonin reuptake, tesofensine may influence sleep-wake cycles, sleep architecture, and sleep continuity

The pace of weight return depends partly on how long you took the medication