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Compounded Semaglutide & Tirzepatide in 2026: FDA Rules, Safety Risks, and How to Choose a Legitimate Pharmacy Joshua Silva, MD Oct 3, 2025 5 min read Updated: Jan 21 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As of 2026, compounded semaglutide and tirzepatide are no longer broadly permitted in the United States

doi: 10.1038/s41401-018-0169-5 144 ZhangMGaoMChenJSongLWeiW

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Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap