semaglutide causing constipation Does Taking Cause Constipation? Can Ozempic (semaglutide) cause constipation

Ozempic Class * GLP-1 receptor agonist (Glucagon-like peptide-1 receptor agonist) Generic Name * Semaglutide Indications * Type 2 diabetes mellitus * Reduction of cardiovascular risk in selected patients with type 2 diabetes and cardiovascular disease * Weight loss (semaglutide is also marketed in some settings under a different brand for obesity management) Mechanism of Action * Stimulates glucose-dependent insulin secretion * Suppresses glucagon secretion * Delays gastric emptying * Increases satiety and reduces appetite Dosage (Type 2 Diabetes) * 0.25 mg subcutaneously once weekly for 4 weeks * Increase to 0.5 mg once weekly * May increase further based on response and local prescribing guidance Adverse Effects Common * Nausea * Vomiting * Diarrhea * Constipation * Abdominal pain * Reduced appetite Serious * Acute pancreatitis * Gallbladder disease * Acute kidney injury (usually secondary to dehydration) * Severe gastrointestinal symptoms Contraindications * Hypersensitivity to semaglutide * Personal or family history of medullary thyroid carcinoma * Multiple endocrine neoplasia syndrome type 2 (MEN2) Precautions * History of pancreatitis * Severe gastrointestinal disease * Renal impairment with significant dehydration risk Drug Interactions * May affect absorption of oral medications due to delayed gastric emptying * Risk of hypoglycemia increases when used with insulin or sulfonylureas Monitoring * HbA1c * Fasting/random blood glucose * Weight * Renal function if significant GI side effects occur * Active ingredient: Semaglutide * Administration: Subcutaneous injection once weekly * Causes significant weight loss and improves glycemic control

A.KumarA.et al

Included animals were then randomized into treatment groups based on mean baseline PSR area% 1 week before dose start

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