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Within this formula, N denotes the sample size for the exposure, K represents the number of instrumental variables, EAF is the effect allele frequency, is the effect size, and SE is the standard error of the effect size ( 2.3 Two-sample Mendelian randomization The present study primarily employs the inverse-variance weighted (IVW) method, weighted median (WM), MR-Egger, Weighted mode, simple mode, and Wald Ratio for analysis

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