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Some studies indicate people with obesity have low vitamin B12 levels

As a general clinical principle: Retest HbA1c no sooner than three months after commencing B12 replacement therapy, and ideally once haematological recovery has been confirmed Confirm haematological recovery normalisation of MCV and haemoglobin before interpreting the repeat HbA1c as reliable Use interim glucose monitoring such as fasting plasma glucose, OGTT, or self-monitored blood glucose (SMBG) to assess glycaemic control during the treatment period

Aged muscle stem cells treated with NNMT inhibitors regain proliferative capacity and regenerative function, reversing cellular senescence that normally accumulates with age

J Clin Invest 86 : 265272 Mauras N and Haymond MW (2005) Are the metabolic effects of GH and IGF-I separable