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The SURMOUNT-1 clinical trial tracked weight loss outcomes across all three maintenance dose tiers over 72 weeks in adults with obesity or overweight

Most experts recommend long-term or indefinite use, transitioning to a maintenance dose rather than stopping completely, combined with sustained lifestyle changes

This guide covers everything: the clinical evidence behind the combination, exactly how each medication works at the cellular level, practical protocols for taking both, strategies for managing overlapping side effects , and the specific situations where your prescriber might adjust one or both medications

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