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The current 4-week-per-dose-level schedule was specifically designed to minimize GI side effects while reaching therapeutic doses in a reasonable timeframe

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The decrease in urinary 3-methylhistidine levels contrasts with its typical increase associated with muscle wasting and cachexiacharacterised by significant unintentional weight losscommonly observed in TB patients (Luies & Du Preez, 2020)

The renal pelvis was cannulated with a 32 G triple-lumen catheter (ReCathCo, Allison Park, PA) via the ureter for intrapelvic perfusion and withdrawal of infusate and monitoring of pelvic pressure