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doi:10.1155/2015/648108 Philp D, Goldstein AL, Kleinman HK
The interplay between the somatotropic axis and sleep regulation has been extensively documented in both preclinical and clinical studies, demonstrating the integral role of growth hormonereleasing hormone (GHRH), somatostatin, GH itself, insulin-like growth factor-I (IGF-I), synthetic GH secretagogues, and ghrelin in modulating sleep architecture ( In normal individuals, sleep-onset GH secretion appears to be primarily regulated by GHRH stimulation during a period of relative somatostatin withdrawal
As we get older, the levels of GHK in the bloodstream is lower, making it more difficult for the skin to repair itself to its youthful appearance
Heck: This work was supported by the National Institutes of Mental Health R01MH112143 to DHH
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