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additionally, acute exercise lasting 1 h increased NAD + , NAMPT, and ATP levels in PBMCs while decreasing serum NAM levels, suggesting an increase in NAD + salvage pathway 326

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This intervention alleviated abnormalities in iron homeostasis, lipid peroxidation, and antioxidant system damage, inhibited ferroptosis, and improved neurological damage and cognitive dysfunction

Red blood cells contain relatively high concentrations of reduced glutathione (GSH), a sulfhydryl-containing tripeptide (glutamylcysteinylglycine) which functions as an intracellular reducing agent that protects cells against oxidant injury