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In this context, it is emphasized that the Chronobiological Feeding Model should be addressed more extensively in studies and that its effects on infants should be examined in a more comprehensive manner

In addition, as an epigenetic modification, DNA methylation can be involved in disease progression and serve as a marker of environmental exposures, such as tobacco smoking, lipid peroxidation, and inflammation ( GSTA4 promoter, which contains antioxidant response elements, may act as an adaptive mechanism through which they are transcriptionally activated during exposure to lipid peroxidation of the vascular wall in IA patients ( GSTA4 methylation may serve as a biomarker of vascular impairment in patients with IA

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The pathogenesis of PD is complex and still not fully understood