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In this context, one could assume that degradation of chondroitin sulfate proteoglycans in melatonintreated nerves (Krityakiarana et al., 2016) could depend on activation of the proteases with melatonin, in contrast to other tissue types where melatonin inhibits the MMPs

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These included drug-related emergency department visits, hospitalizations, overdoses, deaths, and suicidal thoughts or attempts