semaglutide criteria for use Once-Weekly Versus Sodium-Glucose Co-transporter 2 Inhibitors: Real-World Impact on Weight, HbA1c, and Healthcare Resource Utilization in Type 2 Diabetes (PAUSE) | Diabetes Therapy Who Qualifies for Semaglutide GLP-1

A 20% reduction sounds significant, but this is likely the relative risk reduction, which doesnt give us a complete picture of the relationship between semaglutide and heart disease risk

Mechanistically, ketogenic metabolic therapy has been proposed to i) enhance mitochondrial biogenesis and energy efficiency, ii) reduce oxidative stress and systemic inflammation, iii) modulate glutamatergic neurotransmission and iv) increase BDNF expression and neuroplasticity

Semaglutide ability to address all three of these pathways simultaneously may explain the robust kidney protection observed

Since mitochondria are highly compartmentalized organelles requiring specific transporters for the movement of metabolites and molecules, the transportation of endogenously expressed MOTS-c within organelles by transporters such as SLC25 family and between cells or tissues require further investigation