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In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig

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Neutralizing harmful free radicals

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The normal levels may vary slightly between different labs but generally below 140pmol/L is considered a deficiency

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168 ZanganehS.HutterG.SpitlerR.LenkovO.MahmoudiM.ShawA.et al (2016)

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