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Newer triple agonists Retatrutide , the investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, showed higher overall GI event rates in Phase 2 trials at its highest doses

This cardiovascular benefit is now part of the FDA-approved indication for Wegovy

Axi-cel (Yescarta) was the asset, and Kites IP position was anchored by an exclusive license to the Eshhar 465 patent, a foundational claim on chimeric antigen receptor constructs

Nevertheless, other works have shown that oocytes are more sensitive to heat stress than cumulus cells are 75 and that long-term exposure to heat stress conditions may overwhelm the protection capacity of cumulus cells 82