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The synovium that lines the knee joint capsule, producing synovial fluid to lubricate the joint and reduce friction, can become inflamed, thickening the capsule

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While passive diffusion was initially proposed as the main absorption route, recent evidence indicates that specific transmembrane transporters including Na-taurocholate cotransporting polypeptide, organic anion-transporting polypeptides, L-type amino acid transporters, and monocarboxylate transporters also facilitate LT4 uptake

Qsymia combines a weight-loss stimulant with an epilepsy drug, carrying risks of abuse, heightened heart rate, and possible birth defects