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While hypoglycemia may indicate the severity of underlying conditions rather than being a direct cause of death, the current understanding does not distinguish a causal relationship, therefore requires strategies to avert preventable hypoglycemia [977]

Patients taking antihypertensive medicines or diuretics should discuss this with their clinician, as dose adjustments may be needed

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Early disease onset, higher levels of hyperglycaemia, and the multiple cardiometabolic risk factors found in adolescents and young adults with impaired glucose tolerance and/or impaired fasting glucose and diabetes all contribute to an increase in risk of adverse outcomes [267]