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In STAT3-knockdown MCECs (siSTAT3-transfected), GHK-Cu failed to enhance wound healing in scratch assays (Figures 7A,B) and did not upregulate ZO-1/Occludin expression (Figures 7CF)

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The trial involved 1879 patients with inadequate glycemic control on metformin monotherapy, who were randomly assigned to receive tirzepatide at doses of 5 mg, 10 mg, or 15 mg, or semaglutide at a dose of 1 mg.After 40 weeks of treatment, all doses of tirzepatide were found to be noninferior and superior to semaglutide in terms of reducing glycated hemoglobin (HbA1c) levels