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Its receptors are expressed in multiple tissues, including the heart, kidneys, lungs, and smooth muscle

Notably, weight loss continued after the early transition from weekly to monthly dosing, with no evidence of a plateau at week 28

One way delayed gastric emptying can contribute to an intestinal blockage is through mechanical obstruction

Importantly, serum B12 levels can be misleadingly normal or even elevated in chronic liver disease due to increased levels of binding proteins (such as haptocorrin) and reduced clearance, meaning that total B12 measurements may not accurately reflect tissue B12 status or functional deficiency