In: Goldman L, Cooney KA, eds
Intrinsic factor is a protein needed so that B12 can be absorbed
The labeling for both Mounjaro and Ozempic carry Boxed Warnings for possible thyroid tumors, including cancer, which has been seen in animal studies
The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)