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For example, in adult rats, short-term abstinence (e.g., 24 h) following repeated nicotine injections produces anxiety-like responses in the elevated plus maze ( Previous studies that showed ASA (15 mg/kg for 11 days) reduces chronic ethanol intake and relapse to binge-drinking (Israel et al., 2021), and attenuates reinstatement of oral nicotine intake (Quintanilla et al., 2020)

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