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Chronic wound healing: A review of current management and treatments

These conditions of excessive lipid toxicity and metabolic load eventually lead to the accumulation of liver lipids, cell damage, inammation, and brosis (187,188)

Hypertension was defined as systolic/diastolic blood pressure 140/90 mmHg or ongoing treatment with antihypertensive agents

Therefore, a deeper understanding of the regulatory and signaling mechanisms of NAC on macrophages and other innate immune cells involved in bone metabolism will further inform its application in bone tissue engineering