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and (3) pain defined as distal extremity pain plus one of the following: dysesthesia, burning/painful feet worsening at night or intolerance of sheets/clothes touching the legs or feet

Studies have shown that B-12 positively affects the brain, helping reduce stress and improve cognitive functioning

Mechanisms underlying cardiac protection include enhanced coronary angiogenesis, antioxidant effects reducing oxidative damage, anti-inflammatory modulation limiting inflammatory cell infiltration, and direct cardiomyocyte protection

The actual B12 remains in your system longer, but active levels gradually decline as your body utilises it