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Semaglutide: Single-Receptor Approach Semaglutide activates the GLP-1 receptor, producing the following effects: Appetite suppression through direct action on hypothalamic neurons that control hunger signaling Delayed gastric emptying that promotes prolonged feelings of fullness after meals Enhanced glucose-dependent insulin secretion from pancreatic beta cells Reduced glucagon secretion (different from glucagon receptor activation) that lowers hepatic glucose output Potential neuroprotective effects currently being studied in Alzheimers disease trials Research by Blundell et al