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This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)
Instruct patients to contact their healthcare provider if they have severe or persistent gastrointestinal symptoms [see Warnings and Precautions (5.7)]
Signs and symptoms of multisystem inflammatory syndrome in children (MIS-C) include those below - Fever that lasts more than 3 days Vomiting, diarrhea and stomach pain are particularly common and prominent Skin rash Conjunctivitis - red eyes Mucous membrane involvement - Redness or swelling of the lips and tongue Headache, dizziness, or lightheadedness Rapid breathing Sore throat Body pain Redness or swelling of the hands or feet Enlarged lymph nodes Emergency warning signs of MIS-C Severe stomach pain Difficulty breathing Pale, gray or blue-colored skin, lips or nail beds Inability to wake up or stay awake Diagnosis of Multisystem Inflammatory Syndrome Doctors may want to do tests such as blood tests, or imaging tests of the chest, heart or abdomen to check for areas of inflammation and other signs of MIS-C
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