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If stomach pain or nausea becomes severe, discuss holding at your current dose for an additional 1 to 2 weeks with your provider before increasing further

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Nevertheless, the GSTM1*0/GSTT1*0 genotype has been shown to be a potential genetic risk factor for essential hypertension (40), and it has been reported that genetic loss of the GSTT1 enzyme is an independent and powerful predictor of premature vascular morbidity and death in individuals with type 2 diabetes (41)

Implications A wide range of contemporary environmental factors (food and air quality, toxic exposures etc.) can converge to deplete antioxidant resources within and across generations, progressively increasing the prevalence of individuals with oxidative stress and related impairment of methylation [128]