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Synergistic Efficacy of CPI 613 Combined with Enz in PCa Treatment CPI 613, a novel PDHA1 inhibitor, has demonstrated antitumor activity by disrupting mitochondrial metabolism through phosphorylation and inactivation of PDHA1, which plays a key role in PCa cell survival, and exhibits low toxicity to normal prostate epithelial cells (RWPE1) while effectively killing PCa cells (Supplementary Fig

Warnings Patients who have early Leber's disease (hereditary optic nerve atrophy) have been found to suffer severe and swift optic atrophy when treated with vitamin B12

L-Carnitine is an amino acid derivative which is naturally produced in the body, including the brain, liver, and kidneys

NDA 19-998/S-013