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The two synthetic GPR40-specific compounds AM-1638 and AM-5262, have been found to act as double Gq and Gs agonists but also as positive allosteric modulators, capable to enhance the GLP-1-secreting capabilities of Gq-only agonists such as dietary docosahexaenoic (DHA) and -linolenic acid (ALA), independently of the orthosteric site (265)
But while most conversations focus on external solutions, theres a more foundational question worth asking: What is GLP-1 and how does your body produce it naturally
Goncharova ND, Khavinson BK, Lapin BA
doi:10.1016/j.bbagen.2012.09.008
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