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PIONEER 9 was a 52-week, phase 2/3a, randomized, controlled trial to assess the efficacy, dose response, and safety of oral semaglutide monotherapy (3, 7, or 14 mg) compared with placebo and liraglutide 0.9 mg in 243 Japanese patients with type 2 diabetes uncontrolled on diet and exercise or one oral glucose-lowering drug (washed out during run-in) [52]

Clinical trial data from the STEP 4 and STEP 5 studies showed that participants who continued semaglutide maintained meaningful weight loss over one to two years, even though the rate of loss flattened compared with the earliest weeks